As a seasoning, it spans continents, finding its way through Thai, Indian, Chinese, and other Asian cuisines, and into western baked goods, ales, and sauces. As a supplement, it provides valuable minerals, bridging the gap between diet and medicine.
In his doctoral thesis, Lic. Juri Timonen also developed new analytical methods for the fast identification of natural and non-natural coumarins. A few of the synthesised coumarins were also found to inhibit some specific reactions generally associated with inflammation.
Coumarin is an aromatic compound, naturally occurring in many plants. In foodstuffs coumarins are found especially in cinnamon and tonka beans. The bioactivity of coumarins has been utilised in many drugs; for example, coumarins exhibit anti-inflammatory as well as anticoagulant activities.
The study made considerable improvements to the decades-old synthesis method of coumarins. Most of the previous methods are based on heating of the starting material with a strong acid, but the newly developed method also works at room temperature.
The improvements also lower the production costs, since the final products are easier to purify. A commonly used inflammation model showed that some of the synthesised coumarins remarkably reduced the production of typical signalling molecules, such as nitric oxide synthase and nitric oxide itself, which are usually linked to inflammation.
In this assay, a murine cell line from mice imitated the inflammatory response. The results also revealed one of the pathways in which coumarins act.
Understanding of this pathway and data on nearly 50 tested coumarins may help in the development of future anti-inflammatory drugs for chronic inflammation diseases such as asthma and rheumatoid arthritis. Developing new analytical methods for natural and non-natural compounds is important in the screening of natural products with biological activity as well as in studies of drug metabolism.
By using a mass spectrometric method developed in this study, even very similar compounds can be distinguished and characterized based on their fragmentation during the analysis.
A fragmentation pattern for a given molecule obtained by a mass spectrometer resembles a fingerprint; it is dependent only on the structure of the molecule and two non-identical molecules produce different patterns.
The study revealed some interesting details on the fragmentation of synthesized coumarins. This knowledge can be used in the future to predict fragmentation of novel coumarins. For further information, please contact Researcher Juri Timonen:Fluorescence studies of coumarin labelled nanocrystalline cellulose By Timothy Mack Submitted in partial fulfilment of the requirements of the degree.
A pharmacognostic study was made of the root of Heracleum mantegazzianum, an umbelliferous species which is of value as a source of natural coumarins.
Three groups of seeds were tested to determine the presence of a germination requirement for moist cold and the possible value of gibberellic acid in. ABSTRACT. Psychotria genus (Rubiaceae) is featured into the angiosperm, being the most speciose genus comprising approximately species.
The available references demonstrate that Psychotria has several uses on traditional medicine including spiritual and cultural purposes, and presents great potential on pharmacological properties, especially the one related to neurodegenerative diseases. 24 Systematic Reviews in Pharmacy, Vol 8, Issue 1, Jan-Dec, Antioxidant Activity of Coumarins ABSTRACT Coumarins are heterocyclic molecules that have been associated with ben -.
thesis, and applications are going to be presented in this chapter. Natural occurring coumarins Coumarin Figure and its derivatives are an important group of natural compounds widely.
Natural Coumarins: Methods of Isolation and Analysis which are extracted with ether and measured by GC . These reactions can be used either jointly with paper chromatography and TLC. European Pharmacopoeia (3rd Edition.